Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I

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<正>The pattern recognition receptors （PRRs） act as the first line of defense against pathogens and are common molecular targets in the conflict between viruses and their host （Tan et al.,2018）.The RIG-I-like receptors （RLRs）,including RIG-I （Yoneyama et al.,2004）,MDA5 （Andrejeva et al.,2004）,and LGP2 （Saito et al.,2007）,are PRRs and reside in the cytoplasm.These proteins recognize the RNA structures of different viral RNA species.All RLRs have an intermediate RNA helicase domain that catalyzes ATP hydrolysis and a C-terminal domain （CTD）.RIG-I and MDA5,but not LGP2,contain tandem caspase recruitment domains at their N-termini

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类型: 期刊论文

作者: Ling Xu,Dandan Yu,Yu Fan,Yi-Ping Liu,Yong-Gang Yao

来源: Journal of Genetics and Genomics 2019年10期

年度: 2019

分类: 农业科技,医药卫生科技,基础科学

专业: 生物学,畜牧与动物医学

单位: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province,Kunming Institute of Zoology,Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province,Sichuan Agricultural University,Kunming College of Life Science,University of Chinese Academy of Sciences,KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases,Kunming Institute of Zoology,Chinese Academy of Sciences

基金: supported by the National Natural Science Foundation of China (U1402224 and 31700155),Yunnan Province (2016FB018),Sichuan Province (2017JZ0033),",the Dawn of West China Talent Training Program of Chinese Academy of Sciences"

分类号: S852.65

页码: 499-503

总页数: 5

文件大小: 1153K

下载量: 13

Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I

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