Histone modifications regulate chromatin compartmentalization by controlling phase separation and its dissolution

论文摘要

<正>Eukaryotic chromosome contains compartments of various functions,which are marked by and enriched with specific histone modifications.However,the molecular mechanism by which histone marks function in chromosome compartmentalization is poorly understood.Heterochromatin is a largely silent chromosome compartment characterized in part by H3K9me2/3.Here we show that heterochromatin protein 1 (HP1),a H3K9me2/3 ‘reader’,interacts with SUV39H1,a H3K9me2/3 ‘writer’,and with Trim28,an abundant HP1 scaffolding

论文目录

文章来源

类型: 国际会议

作者: Pilong Li

来源: 2019 International Symposium of Phase Separation and Phase Transition in Biological Systems 2019-11-14

年度: 2019

分类: 基础科学

专业: 生物学

单位: Tsinghua University

分类号: Q243

DOI: 10.26914/c.cnkihy.2019.040677

页码: 6

总页数: 1

文件大小: 213k

下载量: 4

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