WithD-proline as the reducing and capping agent, fluorescent gold nanoclusters were rapidly prepared（D-Pro@AuNCs） within 10 min at 100℃. In the present of gold nanoparticles, the fluorescence of DPro@AuNCs was remarkably quenched. Interestingly, based on the electrostatic interaction between anticancer drug Raltitrexed and gold nanoparticles induced fluorescence "turn-on" principle, a high selective assay for detection of Raltitrexed was established with the probe associating the fluorescence emission at 435 nm. The fluorescence intensity of D-Pro@AuNCs linearly correlated with the concentration of Raltitrexed in the range from 5.0 mmol/L to 40.0 mmol/L（R2= 0.999） and the limit of detection was 1.9 mmol/L. Further, after Raltitrexed was abdominal injected in rats, a metabolic approach was constructed with the prepared fluorescent probe. It showed great potential of AuNCs-based sensing probes for application in analysis of serum anticancer drugs.
类型: 期刊论文
作者: Weifei Lan,Qiqi Tan,Juan Qiao,Gangyi Shen,Li Qi
来源: Chinese Chemical Letters 2019年09期
年度: 2019
分类: 工程科技Ⅰ辑,医药卫生科技
专业: 化学,材料科学,药学
单位: Beijing National Laboratory of Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Bio-systems, Institute of Chemistry, Chinese Academy of Sciences,School of Pharmacy, Minzu University of China,Department of Chemical Engineering, Beijing Institute of Petro-chemical Technology,School of Chemical Sciences,University of Chinese Academy of Sciences
基金: the financial support from the National Natural Science Foundation of China (Nos. 21575144,91732103,21874138,21635008,21621062)
分类号: O657.3;TB383.1;R96
页码: 1627-1630
总页数: 4
文件大小: 288K
下载量: 6
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