Avian virus infection remains one of the most important threats to the poultry industry. Pathogens such as avian influenza virus（AIV）, avian infectious bronchitis virus（IBV）, and infectious bursal disease virus（IBDV） are normally controlled by antibodies specific for the surface proteins, and cellular immune responses. However, standard vaccines aimed at inducing neutralizing antibodies must be administered annually and can be rendered ineffective since immune selective pressure results in continuous mutation of viral surface proteins of different strains circulating from year to year. Chicken T cells have been shown to play a crucial role in the fight against virus infection, offering lasting and cross-strain protection, and they have the potential for the development of a universal vaccine. This review provides an overview of our current knowledge of chicken T cell immunity to viruses. More importantly, we point out the limitations and barriers of current research, and the potential direction for future studies.
类型: 国际会议
作者: Manman Dai,Chenggang Xu,Weisan Chen,Ming Liao
来源: Grand Challenges in Immunology: Immunotherapy for Cancer and Beyond——The 2nd CMI-NI Joint Conference 2019-06-11
年度: 2019
分类: 基础科学,农业科技
专业: 生物学,畜牧与动物医学
单位: South China Agricultural UniversityLa Trobe University
分类号: S852.65
DOI: 10.26914/c.cnkihy.2019.013511
页码: 112
总页数: 1
文件大小: 115k
下载量: 3
本文来源: https://www.lunwen90.cn/article/76a2665149e16062649c3051.html