Pasteurella multocida causes a variety of infectious diseases in a wide range of mammals and birds, resulting in enormous economic loss to the modern livestock and poultry industry. However, the mechanism of interactions between host and P. multocida are still unclear. Previous studies had found that some amino acids played important roles associated with P. multocida infection. In present work, we found that L-serine concentrations were significantly decreased in murine lungs infected with P. multocida. Intriguingly, exogenous supplementation with L-serine significantly ameliorated the pulmonary inflammatory responses and increased the survival rate of P. multocida-infected mice. Notably, L-serine decreased the macrophage-mediated inflammatory responses in P. multocida infection mice. Mechanistically, L-serine inhibited the production of inflammatory cytokines in macrophages by inhibiting the activation of cellular inflammasome, and inhibiting macrophage polarization though reprogramming the cellular transcription and metabolism. This work initially revealed that the L-serine metabolic cross talk between P. multocida and host, and provided a theoretical basis for the treatment and prevention of diseases caused by this bacterium.
类型: 国际会议
作者: He F.,Wu C.,Xia Y.,Chen S.,Li P.,Zhang H.,Yin Y.,Li N.,Ren W.,Peng Y.
来源: 第十七届国际免疫学大会 2019-10-19
年度: 2019
分类: 基础科学,农业科技
专业: 生物学,畜牧与动物医学
单位: Southwest University,College of Animal Science and TechnologySouth China Agricultural University,College of Animal Science
分类号: S852.6
DOI: 10.26914/c.cnkihy.2019.003192
页码: 181
总页数: 1
文件大小: 398k
下载量: 3
本文来源: https://www.lunwen90.cn/article/11f75703c211453be613b4ec.html