A practical synthesis of β-carbolines by tetra-n-butylammonium bromide （TBAB）-mediated cycloaromatization reaction of aldehydes with tryptophan derivatives

论文摘要

A mild and efficient n Bu4 NBr-mediated oxidative cycloaromatization to prepare β-carbolines from readily available tryptophans and aldehydes is described. The reaction is practical and allows the synthesis of β-carbolines on gram-scale. Some of products crystallized from the reaction mixture and were easily removed by filtration, obviating the need for chromatographic separation.

论文目录

文章来源

类型: 期刊论文

作者: Zhen Wang,Zhenzhen Yu,Yao Yao,Yakai Zhang,Xuefeng Xiao,Bin Wang

来源: Chinese Chemical Letters 2019年08期

年度: 2019

分类: 工程科技Ⅰ辑

专业: 化学

单位: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University,Tianjin University of Traditional Chinese Medicine

基金: National Natural Science Foundation of China (Nos. 21172120 and 21472093),Tianjin Municipal Science and Technology Commission (No. 14JCYBJC20600) for financial support

分类号: O626

页码: 1541-1544

总页数: 4

文件大小: 1441K

下载量: 7

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