Complex formulations, simple techniques: Can 3D printing technology be the Midas touch in pharmaceutical industry?

论文摘要

3 D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3 D printing was developed in the 1980 s and the technology has found widespread industrial applications for production from automotive parts to machine tools,its application in pharmaceutical area is still limited. However,the potential of 3 D printing in the pharmaceutical industry is now being recognized. The ability of 3 D printing to produce medications to exact specifications tailored to the needs of individual patients has indicated the possibility of developing personalized medicines. The technology allows dosage forms to be precisely printed in various shapes,sizes and textures that are difficult to produce using traditional techniques. However,there are various challenges associated with the proper application of3 D printing in the pharmaceutical sector which should be overcome to exploit the scope of this technology. In this review,an overview is provided on the various 3 D printing technologies used in fabrication of complex dosage forms along with their feasibility and limitations.

论文目录

• 1.Introduction
• 2.Additive manufacturing technologies
•   2.1.Laser based writing systems
•     2.1.1.Stereolithography
•     2.1.2.Selective laser sintering（SLS）
•   2.2.Ink-based printing technology:inkjet printing
•   2.3.Material extrusion or nozzle-based deposition system:fused deposition modeling
• 3.Challenges and future of 3D printing in pharmaceutical sector
•   3.1.Concerns regarding quality control and regulatory issues
•   3.2.A tool for personalized medicine
•   3.3.Availability of materials
•   3.4.Resolution of 3D printers
•   3.5.Scale-up manufacturing
• 4.Conclusion
• Conflict of interest

文章来源

类型: 期刊论文

作者: Shrawani Lamichhane,Santosh Bashyal,Taekwang Keum,Gyubin Noh,Jo Eun Seo,Rakesh Bastola,Jaewoong Choi,Dong Hwan Sohn,Sangkil Lee

来源: Asian Journal of Pharmaceutical Sciences 2019年05期

年度: 2019

分类: 医药卫生科技,工程科技Ⅰ辑,信息科技

专业: 有机化工,药学,计算机软件及计算机应用

单位: College of Pharmacy,Keimyung University

基金: supported by Keimyung University Research Grant of 2017

分类号: TP391.73;R943

页码: 465-479

总页数: 15

文件大小: 3639K

下载量: 38