Performance comparison of chlorinated chiral stationary phases in supercritical fluid chromatography for separation of selected pyrrolidone derivatives

论文摘要

The effects of two chlorinated chiral stationary phases,namely,Lux Cellulose-2 and Lux i-Cellulose-5,flow-rate,percentage of co-solvent and chemical structures of the compounds on retention and resolution were studied within this article.In this work a backpressure of 150 bar,a temperature of 40 ℃ and10% of methanol as co-solvent were chosen as operating conditions.The optimum flow-rate was2 mL/min.The percentage of co-solvent was studied between 7.5% and 15%.We have observed that 15% of methanol gave the best results for most of the compounds.For all the derivatives,the Lux Cellulose-2 provided better resolutions going from 1.50 to 3.59 compared with Lux i-Cellulose-5.

论文目录

文章来源

类型: 期刊论文

作者: Anca-Elena Dascalu,Alina Ghinet,Muriel Billamboz,Emmanuelle Lipka

来源: Journal of Pharmaceutical Analysis 2019年04期

年度: 2019

分类: 医药卫生科技,工程科技Ⅰ辑

专业: 化学,药学

单位: Univ.Lille,Inserm,U995-LIRIC-Lille Inflammation Research International Center,Ecole des Hautes Etudes d’Ingénieur(HEI), Laboratoire de Pharmacochimie,UFR Pharmacie, Laboratoire de Chimie Analytique,’Alexandru Ioan Cuza’ University of Iasi, Faculty of Chemistry

基金: supported by the State as part of the ",Programme d’Investissement d’Avenir",under reference ANR10-IEED-0004-01

分类号: R917;O657.7

页码: 248-253

总页数: 6

文件大小: 802K

下载量: 10

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