论文摘要
Gold-based nano materials with plasmonic properties exhibit various potentials for biomedical applications.In this work,gold nanoprisms（GNPs）was synthesized and then modified with LyP-1,a tumo r-homing peptide,to imp rove the affinity of the GNPs to tumor cells,thus,to imp rove the efficacy of tumor-targe ted photothermal therapy.The introduction of NIR dye IR780 not only enabled the GNPsbased nanosystem with the surface-enhanced resonant Raman scattering（SERRS）property,but also enhanced the plasmonic photothermal property which delivering therapeutic heating by 660 nm laser irradiation.The obtained GNPs/IR780-LyP-1 presented significantly increased of photothermal conversion in vitro and in vivo,which resulted in enhanced tumor-targe ting photothermal therapeutic efficacy after laser irradiation.Hence,the GNPs/IR780-LyP-1 prepared in this study can be served as a Raman-encoded molecular imaging candidate and photothermal therapy agents for future cancer treatment.
论文目录
文章来源
类型: 期刊论文
作者: Xi Huang,Yanlong Yin,Min Wu,Wang Zan,Qian Yang
来源: Chinese Chemical Letters 2019年06期
年度: 2019
分类: 工程科技Ⅰ辑,医药卫生科技
专业: 无机化工,材料科学,肿瘤学
单位: The School of Pharmacy, College Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, Chengdu Medical College,Ophthalmic Laboratory and Department of Ophthalmology,State Key Laboratory and Collaborative Innovation Center of Biotherapy, West China Hospital,Sichuan University
基金: financially supported by the Application Fundamental Research Foundation of Sichuan Province Science and Technology Department,China (No. 2016JY0157),the State Sponsored Scholarship for Visiting Scholar from China Scholarship Council,the Outstanding Science and Technology Projects for Returned Overseas Chinese Scholars,Sichuan Province,China,theNational Natural Science Foundation of China (No. 31600811),the National Training Program of Innovation and Entrepreneurship for Undergraduates(No. 201813705025)
分类号: R730.5;TQ131.23;TB383.1
页码: 1335-1340
总页数: 6
文件大小: 1330K
下载量: 5