论文摘要
Folate-targeting self-assembled nanoparticles（NPs） using biocompatible and biodegradable natural polymers chitosan（Cs） and chondroitin sulfate（Chs） were developed to address the major challenge in cancer treatment, the selective delivery of nanoparticles to the target site. In this study, we successfully incorporated a hydrophobic drug, bortezomib（Bor）, into folic acid（FA）-conjugated Cs/Chs self-assembled NPs（Bor/Cs/Chs-FA） for colorectal cancer therapy. The particle size and polydispersity index of Bor/Cs/Chs-FA were 196.5 ± 1.2 nm and 0.21 ± 0.5, respectively. A pH-dependent release profile was observed, facilitating cancer cell-targeted drug release under an acidic tumor microenvironment. Moreover, in vitro data revealed enhanced cellular uptake and apoptosis in folate receptor-expressing colorectal cancer cells（HCT-116 and HT-29） as compared to that in lung cancer cells（A549）, which do not express folate receptors. Furthermore, intravenous administration of Bor/Cs/Chs-FA in a HCT-116 bearing xenograft mouse model showed that the NPs were a safe and effective drug delivery system. The results suggest that folate-targeted nanoparticle can be effectively applied for efficient chemotherapy of colorectal cancer.
论文目录
文章来源
类型: 期刊论文
作者: Zar Chi Soe,Bijay Kumar Poudel,Hanh Thuy Nguyen,Raj Kumar Thapa,Wenquan Ou,Milan Gautam,Kishwor Poudel,Sung Giu Jin,Jee-Heon Jeong,Sae Kwang Ku,Han-Gon Choi,Chul Soon Yong,Jong Oh Kim
来源: Asian Journal of Pharmaceutical Sciences 2019年01期
年度: 2019
分类: 医药卫生科技,工程科技Ⅰ辑
专业: 有机化工,药学
单位: College of Pharmacy, Yeungnam University,Department of Pharmaceutical Engineering, Dankook University,College of Korean Medicine, Haany University,College of Pharmacy, Hanyang University
基金: supported by the Yeungnam University research grant in 2017
分类号: R943
页码: 40-51
总页数: 12
文件大小: 3318K
下载量: 14
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