Structure of a substrate engaged SecA-SecY protein translocation machine

Structure of a substrate engaged SecA-SecY protein translocation machine

论文摘要

<正>Protein translocation through a protein-conducting channel, SecY/Sec61, is a universal cellular process in both prokaryotes and eukaryotes. In prokaryotes, the SecY channel cooperates with an ATPase, SecA, to move the secretory proteins across the membranes after protein translation. It was unclear how the SecA-SecY complex translocates its highly diverse protein substrates. We assembled a protein translocation intermediate consisting of SecA, SecY, and a polypeptide substrate, and determined its cryo-electron microscopy structure in the lipid

论文目录

文章来源

类型: 国内会议

作者: 李龙

来源: 第六届全国冷冻电子显微学与结构生物学专题研讨会 2019-06-16

年度: 2019

分类: 基础科学

专业: 生物学

单位: School of Life Sciences, Peking University

分类号: Q51

DOI: 10.26914/c.cnkihy.2019.038774

页码: 30

总页数: 1

文件大小: 170k

下载量: 5

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Structure of a substrate engaged SecA-SecY protein translocation machine
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