赵燕妮1武革1（通讯作者）陈玉华2伍晓聪1
1.广东医科大学附属医院内分泌科广东湛江524001；2.深圳市龙岗区人民医院内分泌科广东深圳518116
【摘要】目的观察骨质疏松患者高血压与骨形成指标骨钙素（OC）的相关性。方法对452例大于50岁骨质疏松患者进行横断面研究，观察高血压与OC的相关性。用电化学发光免疫分析测定骨形成标志物。结果根据血压水平将所有患者分为高血压组及无高血压组，按性别分层，校正可能的混杂因素后，女性高血压组OC水平低于无高血压组，而男性高血压组OC水平与无高血压组无统计学差异。结论高血压病与女性中老年骨质疏松患者低骨钙素水平相关，可能是该人群骨量低下及骨质疏松发生的风险因素之一，但结论仍有待进一步研究证实。
【关键词】骨质疏松；高血压；骨钙素；相关性
Correlationanalysisofhypertensionandboneformationmarkersinosteoporosispatients
ZHAOYan-ni1，WUGe1（correspondingauthor），CHENYu-hua2，WUXiao-cong1
（1.DepartmentofEndocrinology，AffiliatedHospitalofGuangdongMedicalUniversity，Zhanjiang，Guangdong，524001；2.DepartmentofEndocrinology，
ShenzhenLonggangpeople'sHospital，Shenzhen，Guangdong，518116）
Abstract：ObjectiveToinvestigatetheCorrelationofhypertensionwithboneformationmarkersosteocalcin（OC）inChineseOsteoporosispatients.MethodsAcross-sectionalstudywith452（＞50years）Chineseosteoporosispatientswascarriedout.TheCorrelationofhypertensionwiththeboneformationmarkersofOCwasobservedandtheOCconcentrationweremeasuredbyECLimmunoassay.ResultsThepatientswerepidedintohypertensiongroupandnohypertensiongroupaccordingtothebloodpressurelevel.Afteradjustingformultipleconfounders，theOClevelinhypertensiongroupwerelowerthanthatinnohypertensiongroupofwomenpatients.However，therelationshipbetweenhypertensionandboneformationmarkersinmenpatientswasfoundnosignificantdifference.ConclusionHypertentionwasassociatedwiththelowerOClevelinChineseosteoporosisoffemalepatients，anditmightbetheriskfactorforlowbonemineraldensityandosteoporosis，however，therelativeconclusionneedtobeconfirmedbyfurtherstudies.
Keywords：Osteoporosis；hypertention；osteocalcin；relevance