Fabrication of shish-kebab-structured carbon nanotube/poly（ε-caprolactone） composite nanofibers for potential tissue engineering applications

论文摘要

The electrospinning process was applied to fabricate the nanofibers of biodegradable poly（ε-caprolactone）（PCL） in which different contents of multiwalled carbon nanotubes（MWCNTs） were embedded. Afterward,the electrospun nanofibers were successfully decorated with shish-kebab structure via a self-induced crystallization technique. The topographical features and the mechanical properties of the composite scaffolds were characterized,and the biocompatibility of the material was assessed by using human osteogenic sarcoma osteoblasts（MG-63 cells）. The carbon nanotube（CNT） concentration is found to affect the fiber diameter and mechanical properties of electrospun nanofibers and the periodic distance of the shish-kebab architecture. Cellular attachment and proliferation assays reveal that 0.5 wt% CNT-embedded PCL scaffold shows enhanced biocompatibility with MG-63 cells than their counterparts made of neat PCL, and the collagen-like nanotopology provided by the shish-kebab structure further facilitates the cell adhesion and proliferation. The superior interactions between cells and scaffolds demonstrate that the shish-kebab-structured CNTs/PCL nanofibers may be promising candidate for tissue engineering scaffold application.

论文目录

文章来源

类型: 期刊论文

作者: Tong Wu,Xin Chen,Jin Sha,Yi-Yan Peng,Yu-Lu Ma,Lin-Sheng Xie,Lih-Sheng Turng

来源: Rare Metals 2019年01期

年度: 2019

分类: 工程科技Ⅰ辑

专业: 有机化工

单位: Engineering Center of Efficient Green Process Equipment and Energy Conservation, Ministry of Education, East China University of Science and Technology,School of Mechanical and Power Engineering, East China University of Science and Technology,Wisconsin Institute for Discovery, University of Wisconsin-Madison

基金: financially supported by the Fundamental Research Funds for the Central Universities (No. 22A201514030),China Postdoctoral Science Foundation (No. 2015M571504),the National Natural Science Foundation of China (Nos. 51503065 and 51273065),the Wisconsin Institute for Discovery in University of Wisconsin-Madison,China Scholarship Council

分类号: TQ342.87

页码: 64-72

总页数: 9

文件大小: 1619K

下载量: 8

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