论文摘要
Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components.This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal.Recently, much work has been done describing antibiotic resistance genes in various environments; now quantitative, mechanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.
论文目录
文章来源
类型: 期刊论文
作者: James M.TIEDJE,WANG Fang,Célia M.MANAIA,Marko VIRTA,SHENG Hongjie,MA Liping,ZHANG Tong,Edward TOPP
来源: Pedosphere 2019年03期
年度: 2019
分类: 农业科技,工程科技Ⅰ辑
专业: 环境科学与资源利用
单位: Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences,Center for Microbial Ecology, Department of Plant, Soil and Microbial Sciences, Michigan State University,University of Chinese Academy of Sciences,Department of Microbiology, University of Helsinki,Environmental Biotechnology Lab, The University of Hong Kong,London Research and Development Centre, Agriculture and Agri-Food Canada and University of Western Ontario
基金: funded by the National Natural Science Foundation of China (No. 21677149),the Outstanding Youth Fund of the Natural Science Foundation of Jiangsu Province,China (No. BK20150050),the Innovative Project of Chinese Academy of Sciences (No. ISSASIP1616),funded by the Center for Health Impacts of Agriculture (CHIA) of Michigan State University,USA,funded by Agriculture and AgriFood Canada,the Canadian Genomics Research Development Initiative (GRDI-AMR),the Canadian Institute for Health Research (CIHR) through the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR),the National Funds from FCT—Funda??o para a Ciência e a Tecnologia,Portugal (No. UID,Multi,50016,2013),funded by Academy of Finland and the Joint Programming Initiative “Water Challenges for a Changing World” (Water JPI),funded by the Collaborative Research Fund of Hong Kong (CRF),China (No. C6033-14G)
分类号: X703
页码: 273-282
总页数: 10
文件大小: 215K
下载量: 23