Effect of fosfomycin,Cynara scolymus extract,deoxynivalenol and their combinations on intestinal health of weaned piglets

论文摘要

Weaning is a challenging stage of pig farming.Animals undergo environmental,social and dietary changes leading to weaning stress syndrome.In order to compensate for the detrimental effects of weaning stress,antibiotics and natural extracts are used as feed additives,sometimes without fully understanding the interactions between them or even with low concentrations of mycotoxins that are frequently present in feed.The aim of this study was to evaluate the effect of fosfomycin（FOS）,Cynara scolymus extract（CSE）,deoxynivalenol（DON） and their combined administration on intestinal health of weaned piglets.The experiment was designed as a 2×2×2 factorial arrangement with 3 factors（FOS,CSE and DON treatments）,2 levels each（presence and absence） and 3 repeats.Weaned piglets（n=24）were randomly divided in groups to receive the different treatments,namely DON administered in diet（50 μg/kg BW）,FOS administered into the drinking water（30 mg/kg BW）,CSE administered in diet（15 mg/kg BW） and all their combinations.After 15 d,the animals were euthanized and gastrointestinal tract samples were immediately taken to evaluate gastrointestinal pH,Enterobacteriaceae to lactic acid bacteria（E:L） ratio,volatile fatty acid（VFA） concentrations,disaccharidase（lactase,sucrase and maltase）activity,histology（intestinal absorptive area [IAA] and goblet cells count） and mucus ability to adhere pathogenic Escherichia coli.From our results,FOS and CSE treatments,individually or combined,produced a lower E:L ratio,an enhanced production of butyrate,increased disaccharidase activity（particularly maltase）,and a greater IAA and goblet cells count along with an increase in pathogenic bacteria adherence to intestinal mucus.Deoxynivalenol did not show interactions with the other factors and its administration produced decreases on VFA,disaccharidase activity and goblet cells count.In conclusion,weaning piglets receiving diets containing FOS,CSE or both exhibited evident beneficial intestinal effects compared to animals receiving diets free from these compounds.On the contrary,the presence of DON at sub-toxic concentrations produced detrimental effects on intestinal health.The knowledge of the physiological and pathological gut changes produced by these compounds contributes to understand their potential productive consequences.

论文目录

文章来源

类型: 期刊论文

作者: Guadalupe Martínez,Susana N.Diéguez,María B.Fernández Paggi,María B.Riccio,Denisa S.Pérez Gaudio,Edgardo Rodriguez,Fabián A.Amanto,María O.Tapia,Alejandro L.Soraci

来源: Animal Nutrition 2019年04期

年度: 2019

分类: 农业科技

专业: 畜牧与动物医学

基金: supported by Consejo Nacional de Investigaciones Cientificas y Tecnicas(PICT 2012-2398)from Argentina

分类号: S828.5

页码: 386-395

总页数: 10

文件大小: 1232K

下载量: 7

相关论文文献

• [1].Two mechanically ventilated cases of COVID-19 successfully managed with a sequential ventilation weaning protocol: Two case reports[J]. World Journal of Clinical Cases 2020(15)
• [2].Post-weaning and whole-of-life performance of pigs is determined by live weight at weaning and the complexity of the diet fed after weaning[J]. Animal Nutrition 2017(04)
• [3].Myokine interleukin-15 expression profile is different in suckling and weaning piglets[J]. Animal Nutrition 2015(01)
• [4].Fecal Microbiota Succession of Piglets from Birth to Post-weaning by 454 Pyrosequencing Analysis[J]. Transactions of Tianjin University 2017(03)
• [5].Intermittent suckling with or without comingling of non-littermate piglets before weaning improves piglet performance in the immediate post-weaning period when compared with conventional weaning[J]. Journal of Animal Science and Biotechnology 2017(03)
• [6].Effects of weaning age on growth, nutrient digestibility and metabolism,and serum parameters in Hu lambs[J]. Animal Nutrition 2015(04)
• [7].Plasma metabolomic profiles and immune responses of piglets after weaning and challenge with E.coli[J]. Journal of Animal Science and Biotechnology 2014(03)
• [8].Effect of supplementation with n-3 polyunsaturated fatty acids and/or β-glucans on performance, feeding behaviour and immune status of Holstein Friesian bull calves during the pre-and post-weaning periods[J]. Journal of Animal Science and Biotechnology 2019(02)
• [9].The dynamics of the piglet gut microbiome during the weaning transition in association with health and nutrition[J]. Journal of Animal Science and Biotechnology 2018(04)
• [10].Effects of dietary Selenomethionine supplementation on growth performance,antioxidant status,plasma selenium concentration,and immune function in weaning pigs[J]. Journal of Animal Science and Biotechnology 2015(01)
• [11].Growth Performance of Different Cross Combinations of Quality Lean Type Pig[J]. Animal Husbandry and Feed Science 2013(Z1)
• [12].Modified halloysite nanotubes reduce the toxic effects of zearalenone in gestating sows on growth and muscle development of their offsprings[J]. Journal of Animal Science and Biotechnology 2016(04)
• [13].Effects of Weaning on Immunity and Nutrition in Piglets[J]. Journal of Northeast Agricultural University(English Edition) 2017(03)
• [14].The biological stress of early weaned piglets[J]. Journal of Animal Science and Biotechnology 2013(02)
• [15].Influence of Sows Farrowing Performance on Growth of 21-Day-Old Weaned Piglets and Their Correlation Research[J]. Animal Husbandry and Feed Science 2015(04)
• [16].Automated weaning from mechanical ventilation[J]. World Journal of Respirology 2016(02)
• [17].Weaning stress and gastrointestinal barrier development:Implications for lifelong gut health in pigs[J]. Animal Nutrition 2017(04)
• [18].The development and role of microbialhost interactions in gut mucosal immune development[J]. Journal of Animal Science and Biotechnology 2017(02)
• [19].New fodder and herbal drug slash weaning piglet mortality[J]. Bulletin of the Chinese Academy of Sciences 2008(02)
• [20].Response to weaning and dietary L-glutamine supplementation:metabolomic analysis in piglets by gas chromatography/mass spectrometry[J]. Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012(07)
• [21].The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets[J]. Journal of Animal Science and Biotechnology 2016(04)
• [22].Logistic regression analysis between the weaning outcome of patients with septic shock and EVLWI and ITBI[J]. China Medical Abstracts(Internal Medicine) 2014(03)
• [23].Developmental changes in intercellular junctions and Kv channels in the intestine of piglets during the suckling and post-weaning periods[J]. Journal of Animal Science and Biotechnology 2016(02)
• [24].Effects of Different Additives on Reproductive Performance of Sows and Growth Performance of Piglets under Heat Stress in Summer[J]. Animal Husbandry and Feed Science 2019(Z1)
• [25].Effects of Dietary Yeast Cell Wall Polysaccharides Supplementation to Late Gestation and Lactation Diets on Reproductive Performance and Blood Profiles of Sows and Their Offspring[J]. Animal Husbandry and Feed Science 2018(01)
• [26].Gastrointestinal tract(gut) health in the young pig[J]. Animal Nutrition 2018(02)
• [27].Application of fiberoptic bronchscopy in patients with acute exacerbations of chronic obstructive pulmonary disease during sequential weaning of invasive-noninvasive mechanical ventilation[J]. World Journal of Emergency Medicine 2012(01)
• [28].Association Between the 313 bp Indel in Porcine POU1F1 Gene and Reproduction Traits[J]. Journal of Northeast Agricultural University(English Edition) 2009(03)
• [29].Effects of spermine supplementation on the morphology, digestive enzyme activities, and antioxidant capacity of intestine in weaning rats[J]. Animal Nutrition 2016(04)
• [30].Effects of octacosanol extracted from rice bran on blood hormone levels and gene expressions of glucose transporter protein-4 and adenosine monophosphate protein kinase in weaning piglets[J]. Animal Nutrition 2015(04)