论文摘要
In this study, a novel phenoxyethylamine derivative 1-（bis（4-methoxy phenyl）-methyl）-4-（2-（2-methylphenoxy）ethyl）piperazine（C28 H35 N2 O3, Mr = 454.58） has been synthesized and its structure was characterized by 1 H NMR, 13 C NMR, HRMS and single-crystal X-ray diffraction. The compound crystallizes in triclinic system, space group P1 with a = 6.1980（12）,b = 12.212（2）, c = 19.527（4） ?, α = 93.08（3）°, β = 98.62（3）°, γ = 90.72（3）°, V = 1458.9（5） ?3, Z =2, Dc = 1.035 g/cm3, F（000） = 489, μ = 0.067 mm-1, Mo Kα radiation（λ = 0.71073 ?）, the final R= 0.0693 and wR = 0.1759 for 3030 observed reflections with I > 2σ（I）. The bioassay results indicated that the title compound 5 displayed effective activities against glutamine-induced neurotoxicity in PC12 cells.
论文目录
文章来源
类型: 期刊论文
作者: 仲琰,朱义杰,高雅蓉,许逸,李萍,吴斌
来源: Chinese Journal of Structural Chemistry 2019年07期
年度: 2019
分类: 工程科技Ⅰ辑
专业: 化学,有机化工
单位: School of Chemistry and Chemical Engineering, Southeast University,School of Pharmacy, Nanjing Medical University,School of Basic Medical Sciences, Nanjing Medical University
基金: Supported by the National Natural Science Foundation of China(No.81371451),the Natural Science Foundation of Jiangsu Province(No.BK20131390,BK20151444)
分类号: O626;TQ460.1
DOI: 10.14102/j.cnki.0254-5861.2011-2345
页码: 1093-1098
总页数: 6
文件大小: 404K
下载量: 14
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